Abstract

OBJECTIVE

The purpose of this trial is to obtain etiological profile and neurodevelopmental prognosis of newborns with seizures.

METHODS

Fiftyone patients who were interned in Dr.BehcetUz Children′s Hospital with the diagnosis of neonatal seizure, were prospectively assessed with Bayley-2 developmental test.

RESULTS

Patients between 12–36 months old were included in the trial. 22(%43.1) of them were girl and 29(%56.9) were boys There were no statisticaly significant reletionship between the gender and prognosis. 58.8% were term infant and %41.2 were preterm infants. The birth weight were under 2500gr %52.9 of the patients. There were significant relationship between low birth weight and cognitive dysfunction and sequelae formation (p=0.001). The etiology of seizures most commonly HIE 22(%43.1) patients, 7(%13.7) had hypoglicemia,2(%3.9) had CNS infections, 6(%11.8) had cerebral hemorrhage, 1(%1.9) had cerebral anomaly,1(%1.9) had cerebral infarct. 12(%23.5) patients assumed as idiopathic neonatal seizures. Most common seizure type was subtle seizures with persantage of 45.1. %29.4 were tonic, %19.6 clonic, %5.9 were clonic seizures. Following examination in pediatric neurology polyclinic showed that, 29(%56.9) patient had no seuqelae formation. Spasticity was the most common seuqelae with a percentage of %43.1, and epilepsia formed in %27.5. There were a significant correlation between clonic and myoclonic seizures and sequlae formation. %63 of the patients with sequlae had abnormal EEG activity.According to the Bayley developmental test %54.9 of the patients had low mental and motor performans scores.

CONCLUSION

Risk factors that has influence on the prognosis of patients with neonatal seizures are; etiological diagnosis, seizure type, birth weight, abnormal EEG acitivity and status epilepticus.